Gas Chromatography and Mass Spectrometry: A Practical Guide

The second edition of Gas Chromatography and Mass Spectrometry: A Practical Guide follows the highly successful first edition by F.G. Kitson, B.S. Larsen, and C.N. McEwen (1996). It covers separation conditions for numerous compound types, instructions for the interpretation of mass spectral data, extensive correlations of ion masses and neutral losses with possible structures, and examples of mass spectra to aid in structure determination.

* Covers the practical instruction necessary for successful operation of GC/MS equipment
* Reviews the latest advances in instrumentation, ionization methods, and quantitation
* Includes troubleshooting techniques and a variety of other information useful for the GC/MS practitioner

Preface

Acknowledgments

1. The Fundamentals of GC/MS

1. Introduction








2. Gas Chromatography








3. The GC/MS Interface








4. Mass Spectrometry Instrumentation








5. Mass Spectral Data Interpretation








6. Quantitation with GC/MS

1. GC Conditions, Derivatization, and Mass Spectral Interpretation of
   Specific Compound Types

1. Acids








2. Alcohols








3. Aldehydes








4. Amides








5. Amines








6. Amino Acid








7. Common Contaminants








8. Drugs and Their Metabolites








9. Esters








10. Ethers








11. Fluorinated Compounds








12. Gases








13. Glycols








14. Halogenated Compounds (Other Than Fluorinated)








15. Hydrocarbons








16. Isocyanates








17. Ketones








18. Nitriles








19. Nitroaromatics








20. Nitrogen-Containing Heterocyclics








21. Nucleosides (TMS Derivatives)








22. Pesticides








23. Phenols








24. Phosphorus Compounds








25. Plasticizers and Other Polymer Additives (Including Phthalates)








26. Prostaglandins (MO-TMS Derivatives)








27. Solvents and Their Impurities








28. Steroids








29. Sugars (Monosaccharides)








30. Sulfur Compounds

1. Appendices

1. Definitions of Terms Related to Gas Chromatography








2. Definitions of Terms Related to Mass Spectrometry








3. Atomic Masses and Isotope Abundances








4. Table of X+1 and X+2 Values for Ions Containing Atoms of C and H
   Based on Isotope Contributions








5. Numerical Listing for Peak Intensities of Ions Containing Atoms of Cl and/or Br








6. Steps to Follow in the Determination of an Elemental Composition
   Based on Isotope Peak Intensities








7. Useful Derivatives for GC/MS and Their Effect on Mass Spectra
   of Various Functional Groups








8. GC/MS or LC/MS








9. List of Available EI Mass Spectral Databases








10. List of Information Required for Reporting a GC/MS Analysis








11. List of Third-Party Data Analysis Software








12. Installation of a New Instrument








13. Simple GC Troubleshooting








14. Maintenance, Operating Tips, and Troubleshooting for Mass Spectrometers








15. Mixtures for Determining Mass Spectral Resolution








16. Cross-Index Chart for GC Stationary Phases








17. Ions for Determining Unknown Structures

Index