The Encyclopedia of Mass Spectrometry

Volume 6 serves as a concise review of the current ionization methods used in mass spectrometry today. The majority of chapters include tutorials describing the principles and instrumentation applied to each method. Techniques covered include ionization of gas-phase molecules by particles and photons, ionization of ion-molecule and molecule-molecule reactions, ionization in strong electric fields, spray methods for ionization, desorption ionization by particle bombardment and biophysical applications of desorption and spray ionization. The selection of appropriate methods of ionization for analysis of various substances is also considered.

* reviews range of ionization methods used in mass spectrometry today
* includes tutorials describing the principles and instrumentation applied to each method
* considers appropriate methods of ionization for analysis of various substances

1. Fundamentals of Ionization
2. General Considerations for Ionization
3. Ionization of Gas-Phase Molecules by Particles and at High Temperature: Electron Ionization (EI), Positron Ionization, and Surface Ionization Organic MS
4. Ionization of Gas-Phase Molecules by Photons: Photoionization (PI), Photoelectron Spectroscoy (PES) and Laser Ionization
5. Ionization by Ion-Molecule and Molecule-Molecule Reactions: Chemical Ionization (CI), Atmospheric Pressure Chemical Ionization (APCI), and DART
6. Ionization in Strong Electric Field
7. Spray Methods for Ionization
8. Desorption Ionization by Particle Bombardment: SIMS, Fast Atom Bombardment, and High-Energy Bems
9. Desorption by Photons: Laser Desorption and Matridx-Assisted Laser Desorption Ionization (MALDI)
10. Biophysical Application of Desorption and Spray Ionization
11. Choice of Ionization for Analysis of Various Substances