Comprehensive Medicinal Chemistry II

Computer-assisted Drug Design (CADD) reviews the use of computational methods and how these can aid the drug discovery process. Experts review in-silico approaches for the design and improvement of drug properties. Techniques for modelling, analysing and optimization of properties including potency, selectivity and ADMET are presented. Methods discussed include the Quantitative Structure Activity Relationship (QSAR), ligand and structure-based, lead discovery and new directions. Ideal for students and researchers in chemistry, biochemistry, medicinal chemistry and pharmacology and scientists working in the pharmaceutical industries.

* valuable content now available as an individual volume

* separate volumes will appeal to a wider chemistry, biochemistry and medicinal audience

* priced for individual researcher as well as library purchase

Volume 4 Computer-Assisted Drug Design
Introduction to Computer-Assisted Drug Design
Core Concepts and Methods - Ligand-Based
Core Concepts and Methods - Target Structure-Based
Core Methods and Applications - Ligand and Structure-Based
Applications to Drug Discovery - Lead Discovery
Applications to Drug Discovery - Ligand-Based Lead Optimization
Applications to Drug Discovery - Target Structure-Based
New Directions