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          Progress in Heterocyclic Chemistry (PHC), is an annual review series commissioned by the International Society of Heterocyclic Chemistry (ISHC). Volumes in the series contain both highlights of the previous year's literature on heterocyclic chemistry and articles on new developing topics of particular interest to heterocyclic chemists. The highlight chapters in Volume 21 are all written by leading researchers in their field and these chapters constitute a systematic survey of the important original material reported in the literature of heterocyclic chemistry in 2008. Additional articles in this volume review 'Biocatalytic approaches to chiral heterocycles' and 'Ring-expanded ('fat') purines and their nucleoside/nucleotide analogues as broad-spectrum therapeutics'.
As with previous volumes in the series, Volume 21 will enable academic and industrial chemists, and advanced students, to keep abreast of developments in heterocyclic chemistry in a convenient way.
* Covers the heterocyclic literature published in 2008
* Includes specialized reviews
* Features contributions from leading researchers in their fields
Biocatalytic approaches to chiral heterocycles 
Ring-expanded ('fat') purines and their nucleoside/nucleotide analogues as broad-spectrum therapeutics 
Three-membered ring systems 
Four-membered ring systems 
Five-membered ring systems: 
Thiophenes and Se/Te analogues 
Pyrroles and benzo analogs 
Furans and benzofurans
With more than one N atom  
With N and S (Se) atoms 
With O & S (Se, Te) atoms 
With O & N atoms 
Six-membered ring systems: 
Pyridine and benzo derivatives 
Diazines and benzo derivatives 
Triazines, tetrazines and fused ring polyaza systems (2007) 
Triazines, tetrazines and fused ring polyaza systems (2008)   
With O and/or S atoms 
Seven-membered rings 
Eight-membered and larger rings 
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