Handbook of Neuroemergency Clinical Trials

During the 1990s, scientific advances in understanding the mechanisms and pathophysiology of acute central nervous system. Numerous novel compounds were "tested," and seemingly fell by the wayside. This book is intended to focus on the design and analysis of clinical trials. The authors are aware of the unmet medical need. It represents an acute neurology and neurosurgery. From the knowledge of the patient, the reader can benefit from the 'authors' perspectives.

* Presents new perspectives on acute neuroemergency clinical trials
* Includes insights from clinical pharmacology and industry perspectives
* Discusses historical lessons learned from early and recent trials in acute neuroscience populations

STROKE AND TRAUMA
1. Acute Ischemic Stroke (Christopher Bladin, Stephen Davis)
2. Subarachnoid Hemorrhage (Nader Pouratian, Aaron S. Dumont, Neal F. Kassell)
3. Spontaneous Intracerebral Hemorrhage (Michael D. Hill)
4. Traumatic Brain Injury (Lawrence F. Marshall, Wayne Alves)

CENTRAL NERVOUS SYSTEM EMERGENCIES
5. Acute Seizures and Status Epilepticus (Susan T. Herman)
6. Clinical Trials in Neuro-opthamology (Laura Balcer, Madhura A. Tamhankar)
7. Brain Resuscitation (Edwin M. Nemoto)
8. Clinical Trials in Brain Injury after Cardiac Arrest (Romergryko G. Geocadin, Daniel F. Hanley)

SPECIAL ISSUES IN ACUTE NEUROSCIENCE CLINICAL TRIALS
9. Efficient Dose-Response Finding Strategies for Acute Neuroemergency Treatments (Tom Parke, Michael Krams, Peter Mueller, Don Berry)
10. Biostatistical Issues in Neuroemergency Clinical Trials (Wayne M. Alves)
11. Data and Safety Monitoring Boards (Brett Skolnick)
12. Role of the Project Medical Officer (Joseph Kwentus)
13. Ethical Considerations (Wayne Alves)

PERSPECTIVES ON NEUROEMERGENCY DRUG DEVELOPMENT
14. Industry Perspective on Drug Development (Thomas C. Wessel, Chris Gallen)
15. Regulatory Considerations (Lisa Travis)