NMR Spectroscopy in Pharmaceutical Analysis

For almost a decade, quantitative NMR spectroscopy (qNMR) has been established as a valuable tool in drug analysis. In all disciplines, ie drug identification, impurity profiling and assay, qNMR can be utilized.
Separation techniques such as high performance liquid chromatography, gas chromatography, super fluid chromatography and capillary electrophoresis techniques, govern the purity evaluation of drugs. However, these techniques are not always able to solve the analytical problems. Nevertheless, find out how to international pharmacopoeias. Thus, the aim of qNMR in pharmaceutical analysis.
Ideρ Besρου συνερισμός και την και την συνεργασίας συνεργασίας συνερισμός, water content, polymorphism, and drug formulations, eg tablets, powders. This is a special chapters dealing with representative examples. They give more information by means of concrete examples.

. combines theory, techniques, and concrete applications
. international treatment pharmacopoeias, addressing the concern for licensing
. features of academics and researchers, appealing to a broad readership

Part I: Fundamentals and Techniques . 1. NMR Spectroscopy in drug analysis; application in international pharmacopoeia and related analysses. (U. Holzgrabe, B. Waibel, C. Schollmayer). 2. Principles in NMR spectroscopy. (B. Diehl). 3. qNMR in solid state NMR. (I. Wawer). 4. qNMR. (F. Malz) 5. Internal standards for quantification and pattern recognition, eg ERETIC; and principal component analysis of mixtures, eg beverages (Amix ™). (M. Spraul, E. Humpfer). 6. Microcoil NMR spectroscopy / Nanoliter-Volume NMR spectroscopy. (AG Webb). Part II: General Applications 7. NMR spectroscopy in impurity profiling including aspects of pharmacopoeia. (U. Holzgrabe). 8. NMR spectroscopy of pharmaceutical polymers. (B. Diehl). 9. Natural Products analysis by qNMR. (B. Diehl). 10. Solid-state measurements of drugs and drug formulations. (I. Wawer) Part III Special Applications . 11. NMR assays for the identity of polysaccharides from bacteria. (C. Jones, N. Ravenscroft). 12. Metabolic profiling. (CK Larive). 13. Fluorine-19 and phosphorus-31 NMR for quantitation of fluorinated and phosphorylated drugs and their metabolites in biofluids. (M. Malet-Martino). 14. Solid-state measurements of bones. (C. Jäger). 15. qNMR for assessing the purity of agrochemicals (RJ Wells). 16. Assessment of inhibitors potency of antibiotics by MRI (C. Faber). 17. Quantitation 2D NMR analysis of glycosaminoglycans. (G. Torri). 18. DOSY NMR for Drug Analysis. (M. Malet-Martino, et al). 19. NMR spectroscopy of peptides as an alternative to AAA. (E. Kellenbach, K. Sanders, PLA Overbeeke). 20. The Hypernation of NMR and Other Spectroscopy in Drug and Natural Products Research. (ID Wilson). 21. Online-NMR-Spektroscopy. (H. Hasse)