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Molecular Diagnostics
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  • Molecular Diagnostics
ID: 173842
Wayne Grody, Robert Nakamura, Frederick Kiechle, Charles Strom
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Advances in genomic and proteomic profiling have transformed the field of molecular diagnostics. At the same time as the range of tests for the disease detection and staging is rapidly. Expanding, many physicians. This handbook provides a comprehensive guide to the clinical arena. Other No other No offers No offers No No No No No No No.

* Serves as the definitivereference for molecular pathologists worldwide


* Covers a variety of molecular genetics with the next generation sequencing, somatic cell genotyping, infectious and genetic disease tecting, and pharmacogenetics


* Discusses in the detail issues on assurance, regulation, ethics, and future directions for the science



I. Introduction and Methodology
Quantivative PCR: an introduction
Signal Amplification Methods in Molecular Diagnostics
The Lab-on-a-Chip Approach for Molecular Diagnostics
Nucleic Extraction and Amplification
General Procedures

II. Quality Assurance, Regulatory, and Ethical Issues
Billing and Reimbursement for Molecular Diagnostics
Molecular Pathology and Infectious Diseases
Ethical Considerations in Molecular Diagnostics
Quality Control, Assurance, Identification and Standards

III. Genetic Disease
Molecular Testing for Cystic Fibrosis and CFTR-Related Conditions
Carrier Testing for Neurogenetic Diseases
hemochromatosis
Standards and Recommendations for Molecular Diagnostic Testing for Huntington Disease, the Autosomal Dominant Spinocerebellar Ataxias, and Friedreich Ataxia

IV. Cancer
The Role of Micro-RNAs in Cancer
Molecular Diagnostics in Cancer: Modern Concepts and Overview
Gene Expression Analysis for Tumor Profiling GEA for TP
Molecular Diagnostics of Hematopoetic Malignancies

V. Infectious Diseases
viruses
Hepatic B and C Viruses
Molecular Diagnosis of Cytomegalovirus
Molecular Detection of Multiple Respiratory Viruses


Bacteria
Molecular Methods for Identification and Characterization of Acinetobacter species
Molecular Detection and Surveillance of Healthcare-Associated Infections
Molecular Detection Of Group B Streptococcus
Role of Molecular Techniques in the Epidemiologic Investigation of Hospital-Acquired Infections
Human Papilloma Virus and its Role in Cervical Carcinoma

VI. Specialized Applications of Molecular Testing
Molecular HLA Typing Methods Used in Clinical Laboratories
Identification through DNA analysis in criminal and family relatedness investigations.


VII. Pharmacogenetics
Overview of Pharmacogenomics and Applications for the Modern Clinical Laboratory
UDP-Glucuronosyltransferase 1A1 and the Glucuronidation in Oncology Applications and Hyperbilirubinemia
Pharmacogenetics of P-450 Enzymes
Pharmacogenomics of Thiopurine Methyl Transferase (TPMT): Importance in Monitoring of Mercaptopurine / Azathioprine Therapy

173842

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