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Cancer Drug Design and Discovery
ID: 170899
Stephen Neidle
The ultimate source of information on the development of human genome and cancer genomics projects. These advances have a common understanding of the common solid tumours. Unique sections of the drug. Appealing to a broad audience, it is also an expert in pharmacology, pharmacology, medicine and biological chemistry, and clinicians taking oncology options.
* Covers both currently available as well as those under development
* Provides a clinical perspective on trials of new anticancer agents
* Presents drug discovery examples
Section I. Basic Principles
1. Modern cancer drug discovery: Integrating targets, technologies and treatments
2. Preclinical pharmacology and in vivo models
3. Clinical trial designs for more rapid proof-of-principle and approval
Section II. Methodology
4. Structural biology and anticancer drug design
5. Natural product chemistry and cancer drug discovery
6. Pharmacokinetics & ADME optimization in drug discovery
Section III. Drugs in the clinic and laboratory
7. Temozolomide: from cytotoxic is a molecularly-targeted agent
8. Camptothecins for drug design, cancer cell death and gene targeting
9. Targeting thymidylate synthase by antifolate drugs
Section IV. New Agents
10. Targeting inactive kinases: structure as a foundation for cancer drug discovery
11. Cell cycle inhibitors in cancer: current status and future directions
12. Inhibition of DNA repair as a therapeutic target
13. Heat shock protein-90 inhibitors: targeting the cancer chaperone for combinatorial blockade of oncogenic pathways
14. Heat shock protein-90-directed therapeutics and target validation
15. Inhibitors of tumor angiogenesis
16. The biology and oncology of RAF-ERK signalling P53 as a therapeutic target
Section V. The reality of cancer drugs in the clinic
17. Cancer drug resistance
18. Failure Modes in Anticancer Drug Discovery and Development
* Covers both currently available as well as those under development
* Provides a clinical perspective on trials of new anticancer agents
* Presents drug discovery examples
Section I. Basic Principles
1. Modern cancer drug discovery: Integrating targets, technologies and treatments
2. Preclinical pharmacology and in vivo models
3. Clinical trial designs for more rapid proof-of-principle and approval
Section II. Methodology
4. Structural biology and anticancer drug design
5. Natural product chemistry and cancer drug discovery
6. Pharmacokinetics & ADME optimization in drug discovery
Section III. Drugs in the clinic and laboratory
7. Temozolomide: from cytotoxic is a molecularly-targeted agent
8. Camptothecins for drug design, cancer cell death and gene targeting
9. Targeting thymidylate synthase by antifolate drugs
Section IV. New Agents
10. Targeting inactive kinases: structure as a foundation for cancer drug discovery
11. Cell cycle inhibitors in cancer: current status and future directions
12. Inhibition of DNA repair as a therapeutic target
13. Heat shock protein-90 inhibitors: targeting the cancer chaperone for combinatorial blockade of oncogenic pathways
14. Heat shock protein-90-directed therapeutics and target validation
15. Inhibitors of tumor angiogenesis
16. The biology and oncology of RAF-ERK signalling P53 as a therapeutic target
Section V. The reality of cancer drugs in the clinic
17. Cancer drug resistance
18. Failure Modes in Anticancer Drug Discovery and Development
170899
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