Fluorine and Health

Fluorine and Health presents a crucial global humanitarian issue. The isolated objects are organized in Molecular Imaging, Biomedical Materials and Pharmaceuticals.
Initially the key-position of partially fluorinated low-molecular weight compounds labeled with the natural 19F-isotope for Magnetic Resonance Imaging (MRI) or labeled with the radioactive [18F] -isotope for Positron Emission Tomography (PET) is highlighted. Both non-invasive methods are the most challenging in vivo imaging techniques in oncology, neurology and in cardiology for the diagnosis of diseases.
The manifold facets of fluorinated biomaterials range from inorganic ceramics are perfluorinated organic molecules. Liquid perfluorocarbons are suitable for oxygen transport, and fluorinated polymers are connected to the pathology of blood vessels. Another important issue concerns the application of highly fluorinated liquids in ophthalmology. Moreover, fluorine is an essential trace element in bone mineral, dentine and tooth enamel. The various origins of human exposure to fluoride species on living organisms.
Medicinally relevant fluorinated molecules and their interactions with native proteins. New molecules fluorinated in the strategic position and optimal pharmacological profile. Among the hundreds of marketed active drug components are more than 150 fluorinated compounds. The chapters will illustrate the emergence of pharmaceuticals. Bond Finally bond Finally bond CF bond CF bond CF bond CF bond CF bond CF. CF the bond forming enzyme, is summarized.

- New approach of topics involving chemistry, biology and medicinal techniques
- Transdisciplinar papers on fluoride products
- Importance of fluoride products in health
- Updated data on specific topics

PART I: MOLECULAR IMAGING
1. Fluorine-18 Chemistry for Molecular Imaging with Positron Emission Tomography
Frédéric Dollé, Dirk Roeda, Bertrand Kuhnast, and Marie-Claire Lasne

2. Application of ¹⁸ F-PET Imaging for the Study of Alzheimer's Disease
Kjell Någren and Juha O. Rinne

3. ¹⁸ F-Labeled PET-Tracers for Cardiological Imaging
Klaus Kopka, Stefan Wagner, Michael Schäfers, Andreas Faust, Otmar Schober, and Günter Haufe

4. [ ¹⁸ F] -Labeled PET and PET / CT Compounds in Oncology
Ken Herrmann and Bernd Joachim Krause

5. Non-Invasive Physiology and Pharmacology Using ¹⁹ F Magnetic Resonance
Jian-Xin Yu, Weina Cui, Dawen Zhao, and Ralph P. Mason

PART II: BIOMEDICAL MATERIALS
6. Fluoride-Based Bioceramics
Christian Rey, Christèle Combes, Christophe Drouet, and Hocine Sfihi

7. Fluoride in Dentistry and Dental Restoratives
John W. Nicholson and Beata Czarnecka

8. Fluorinated Biomaterials for Cardiovascular Surgery
Charles Baquey, Marie-Christine Durrieu, and Robert G. Guidoin

9. Fluorinated Molecules in eye surgery: Experimental and Clinical Benefit of a Heavy Oil Silicone Oxane Hd ^® (Mixture of Silicone Oil and RMN3 Fluorine olefin) in the Treatment of Retinal Detachment
I. Rico-Lattes, JC Quintyn, V. Pagot-Mathis, X. Benouaich, and A. Mathis

10. Biocompatibility of Highly Fluorinated Liquids Used in Ophthalmic Surgery
Dirk-Henning Menz and Joachim H. Dresp

11. Perfluorochemical-Based Oxygen Therapeutics, Contrast Agents, and Beyond
Marie Pierre Krafft and Jean G. Riess

12. Exposure of Humans to Fluorine and Its Assessment
Maja Ponikvar

PART III: PHARMACEUTICALS
13. Biological Impacts of Fluorination: Pharmaceuticals Based on Natural Products
Jean-Pierre Bégué and Danièle Bonnet-Delpon

14. Synthesis and Pharmacological Properties of Fluorinated Prostanoids
Yasushi Matsumura

15. Synthesis and Biochemical Evaluation of Fluorinated Monoamine Oxidase Inhibitors
Kenneth L. Kirk, Shinichi Yoshida, and Günter Haufe

16. Fluoroolefin Dipeptide Isosteres: Structure, Syntheses, and Applications
John T. Welch

17. Molecular Interactions of Fluorinated Amino Acids in a Native Polypeptide Environment
Mario Salwiczek, Christian Jäckel, and Beate Koksch

18. Biological Fluorination in Streptomyces cattleya: The Fluorinase
Hai Deng, Fang-Lu Huang, James H. Naismith, David O'Hagan, Jonathan B. Spencer, and Xiaofeng Zhu